Functional pathway mapping analysis for hypoxia-inducible factors
نویسندگان
چکیده
منابع مشابه
SnapShot: Hypoxia-Inducible Factors
Molecular oxygen (O2) is a key substrate for mitochondrial ATP production and numerous intracellular biochemical reactions. The maintenance of O2 homeostasis is therefore essential for the survival of most species. During O2 deprivation, mammalian cells rely on multiple adaptations mediated by the hypoxia-inducible factors (HIFs), mTOR, autophagy, and the ER stress response. This SnapShot will ...
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Tissue hypoxia not only occurs under pathological conditions but is also an important microenvironmental factor that is critical for normal embryonic development. Hypoxia-inducible factors HIF-1 and HIF-2 are oxygen-sensitive basic helix-loop-helix transcription factors, which regulate biological processes that facilitate both oxygen delivery and cellular adaptation to oxygen deprivation. HIFs ...
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ژورنال
عنوان ژورنال: BMC Systems Biology
سال: 2011
ISSN: 1752-0509
DOI: 10.1186/1752-0509-5-s1-s3